Opportunity Information: Apply for SFOP0009226

The Department of State, through the Bureau of International Security and Nonproliferation's Office of the Nonproliferation and Disarmament Fund (ISN/NDF), is offering a discretionary federal funding opportunity focused on the safety and security implications of advanced artificial intelligence during its research and development phase. The grant is framed as an open competition under a Notice of Funding Opportunity (NOFO) and is aimed at producing a comprehensive assessment of how advanced AI systems could create proliferation and broader security risks while they are being developed, tested, and refined. A central theme is the idea that the R&D pipeline itself can introduce unique vulnerabilities, such as the spread of sensitive capabilities, theft or leakage of models or training data, and pathways for advanced AI to be adapted for harmful uses before safeguards are mature.

The work requested is not limited to deliberate misuse. Applicants are also expected to analyze accidental or unintended negative outcomes arising from advanced AI R&D, including misalignment, meaning scenarios where an AI system behaves in ways that are not consistent with human intent, safety constraints, or policy goals. In practice, this points to a wide range of concerns that could include unsafe emergent behaviors, inadequate testing and evaluation, failures in oversight, or operational pressures that encourage premature deployment. The Department indicates a preference for proposals that fully address the stated scope of work, which is described in more detail in Section II of the formal solicitation, suggesting that the strongest applications will likely present a structured, end-to-end assessment rather than a narrow or purely theoretical treatment.

This opportunity is funded through a cooperative agreement, which typically implies a closer working relationship with the government compared with a standard grant, potentially including more coordination, iterative deliverables, or government involvement during performance. The funding activity category is listed under Science and Technology and other Research and Development, and the CFDA number associated with the opportunity is 19.224. The award ceiling is $250,000, with one award expected, so applicants are competing for a single relatively focused project rather than a large multi-award program. Proposals are required to stay within the total funds available under the NOFO.

Eligibility is oriented toward U.S.-based organizations, and the notice states that ISN/NDF invites proposals from non-profit/non-governmental organizations, educational institutions, and for-profit organizations based in the United States. The source data also lists eligible applicants as nonprofits with 501(c)(3) status (other than institutions of higher education), so applicants would need to reconcile these lines by checking the formal solicitation and ensuring their organizational type is clearly allowable. In any case, the target applicant profile is an organization capable of producing policy-relevant, security-informed research on advanced AI risks, especially as they relate to proliferation, misuse pathways, and governance or risk-reduction measures during AI R&D.

Key administrative details include the funding opportunity title, "Advanced Artificial Intelligence (AI) Research and Development (R&D) Safety and Security," and the funding opportunity number SFOP0009226. The opportunity was created on October 26, 2022, with an original application deadline of November 28, 2022. Applicants are directed to consult the full solicitation for the specific application requirements, required formats, and the detailed scope of work, implying that compliance, deliverable structure, and alignment with Section II will be important factors in competitiveness.

  • The Department of State, Bureau of International Security-Nonproliferation in the science and technology and other research and development sector is offering a public funding opportunity titled "Advanced Artificial Intelligence (AI) Research and Development (R&D) Safety and Security" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 19.224.
  • This funding opportunity was created on Oct 26, 2022.
  • Applicants must submit their applications by Nov 28, 2022. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $250,000.00 in funding.
  • The number of recipients for this funding is limited to 1 candidate(s).
  • Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
Apply for SFOP0009226

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Frequently Asked Questions (FAQs)

What is the name of this funding opportunity?

The funding opportunity title is "Advanced Artificial Intelligence (AI) Research and Development (R&D) Safety and Security."

What is the funding opportunity number?

The funding opportunity number is SFOP0009226.

Which federal agency is offering this opportunity?

This opportunity is offered by the U.S. Department of State, through the Bureau of International Security and Nonproliferation (ISN), Office of the Nonproliferation and Disarmament Fund (ISN/NDF).

What type of competition is this?

It is described as an open competition under a Notice of Funding Opportunity (NOFO).

What kind of award mechanism is expected?

The opportunity is funded through a cooperative agreement, which generally indicates a closer working relationship with the government than a standard grant, potentially including coordination during performance and iterative deliverables.

What is the main purpose of the project?

The project is intended to produce a comprehensive assessment of how advanced AI systems could create proliferation and broader security risks during the research and development (R&D) phase, including development, testing, and refinement.

What is meant by focusing on risks during the AI R&D phase?

The emphasis is on vulnerabilities that can arise while AI systems are being built and improved, such as the spread of sensitive capabilities, theft or leakage of models or training data, and ways advanced AI could be adapted for harmful uses before safeguards are mature.

Does the scope focus only on deliberate misuse of AI?

No. The requested work includes both deliberate misuse and accidental or unintended negative outcomes that could arise from advanced AI R&D.

What kinds of accidental or unintended outcomes should be addressed?

The opportunity specifically calls out misalignment scenarios, where an AI system behaves in ways not consistent with human intent, safety constraints, or policy goals. The notice also points toward concerns like unsafe emergent behaviors, inadequate testing and evaluation, failures in oversight, or operational pressures that encourage premature deployment.

How broad is the assessment expected to be?

The Department indicates a preference for proposals that fully address the stated scope of work, implying that stronger applications will likely provide a structured, end-to-end assessment rather than a narrow or purely theoretical treatment.

Where is the detailed scope of work described?

The notice references Section II of the formal solicitation as the place where the scope of work is described in more detail.

What funding category does this opportunity fall under?

The funding activity category is listed under Science and Technology and other Research and Development.

What is the CFDA number for this opportunity?

The CFDA number associated with the opportunity is 19.224.

How much funding is available?

The award ceiling is $250,000, and proposals are required to stay within the total funds available under the NOFO.

How many awards are expected?

One award is expected, meaning applicants are competing for a single award rather than a multi-award program.

Who is eligible to apply?

Eligibility is oriented toward U.S.-based organizations. The notice states that ISN/NDF invites proposals from U.S.-based non-profit/non-governmental organizations, educational institutions, and for-profit organizations.

Is 501(c)(3) status required?

The source information also lists eligible applicants as nonprofits with 501(c)(3) status (other than institutions of higher education). Because the notice contains more than one eligibility description, applicants should confirm eligibility requirements in the formal solicitation and clearly document their organizational status in the application.

What kind of organization is this opportunity looking for?

The described target applicant profile is an organization capable of producing policy-relevant, security-informed research on advanced AI risks, especially related to proliferation, misuse pathways, and governance or risk-reduction measures during AI R&D.

When was the opportunity created?

The opportunity was created on October 26, 2022.

What was the application deadline?

The original application deadline was November 28, 2022.

What should applicants consult to ensure compliance with application requirements?

Applicants are directed to consult the full solicitation for specific application requirements, required formats, and the detailed scope of work, with particular attention to alignment with Section II.

What are examples of vulnerabilities in the R&D pipeline mentioned in the notice?

The notice highlights examples such as the spread of sensitive capabilities, theft or leakage of models or training data, and pathways for advanced AI to be adapted for harmful uses before safeguards are mature.

Does the notice suggest what makes an application competitive?

Based on the information provided, competitiveness is tied to fully addressing the stated scope of work and aligning closely with the detailed requirements described in the formal solicitation (including Section II), rather than submitting a narrow or purely theoretical proposal.

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