Opportunity Information: Apply for RFA DK 27 303
The Kidney Precision Medicine Project (KPMP) Central Hub (CH) funding opportunity (RFA DK-27-303) is an NIH cooperative agreement (U24; clinical trial not allowed) aimed at supporting the core coordinating and leadership center for KPMP. The overall purpose is to drive a unified, project-wide effort to discover and define new biological pathways and clinically meaningful subgroups across acute kidney disease (AKD) and chronic kidney disease (CKD). The long-term intent is to generate the kinds of mechanistic and subgroup insights that make true precision medicine possible, including better-designed, more targeted precision clinical trials in the future (even though this particular award does not support running clinical trials).
At its center, the Central Hub is expected to function as the strategic and operational backbone of the entire KPMP consortium. That includes providing high-level scientific leadership and coordination across participating sites and teams, keeping the consortium aligned around shared goals, standards, and deliverables, and ensuring that the overall program moves efficiently from data generation to interpretable discoveries. A major emphasis of the NOFO is stewardship of advanced computational analyses and the end-to-end data ecosystem: collecting, organizing, integrating, analyzing, and sharing complex KPMP datasets in ways that enable broad discovery, reproducibility, and downstream use by the research community. In addition to computational leadership, the Central Hub is responsible for data management and data sharing practices consistent with open science expectations, meaning the project is designed to promote transparency and community benefit rather than keeping data siloed.
The scope of work for the Central Hub also extends beyond science and informatics into communication, outreach, and business operations. In practical terms, that means the Hub is expected to support consortium communications (internal coordination as well as external engagement), maintain effective outreach that helps disseminate KPMP progress and resources, and handle the operational and administrative functions required to run a multi-site, high-complexity program. The NOFO underscores that KPMP personnel are expected to actively participate in scientific discovery and to promote open science, suggesting that the Central Hub is not just an administrative coordinating center but a scientific driver that helps set standards, priorities, and analytic approaches across the consortium.
This opportunity is offered by the National Institutes of Health under CFDA (Assistance Listing) 93.847 in the health funding activity category. The funding instrument is a cooperative agreement, which typically means NIH will have substantial programmatic involvement compared with a standard grant, and the awardee will collaborate closely with NIH program staff on governance, milestones, and implementation decisions. Only one award is expected under this announcement, so the selected Central Hub will serve as the single, primary coordinating entity for KPMP at the national program level. The original application closing date listed is July 10, 2026, and the opportunity was created on June 3, 2026.
Eligibility is broad across many domestic U.S. organization types, including various levels of government (state, county, city/township, special district), public and state-controlled institutions of higher education, private institutions of higher education, independent school districts, federally recognized Native American tribal governments and other tribal organizations, public housing authorities/Indian housing authorities, nonprofits (both 501(c)(3) and non-501(c)(3), excluding higher education in those categories as specified), for-profit organizations other than small businesses, small businesses, and other eligible entities as permitted by NIH. However, the NOFO is explicit about foreign restrictions: non-U.S. entities are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by the NIH Grants Policy Statement) are not allowed. In other words, the work and supported components must be fully domestic under NIH policy for this award.
In summary, this NOFO is essentially seeking one highly capable, U.S.-based Central Hub to lead KPMP scientifically and operationally, with heavy responsibility for sophisticated computational and data-sharing infrastructure, consortium-wide coordination, and open-science driven dissemination. The goal is to accelerate discovery of kidney disease mechanisms and patient subgroups in AKD and CKD, laying the foundation for future precision approaches and better-targeted clinical research across kidney diseases.Apply for RFA DK 27 303
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Kidney Precision Medicine Project Central Hub (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2026-06-03.
- Applicants must submit their applications by 2026-07-10. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Kidney Precision Medicine Project (KPMP) Central Hub (CH) - FAQs
1) What is this funding opportunity?
This opportunity is the Kidney Precision Medicine Project (KPMP) Central Hub (CH) funding opportunity (RFA DK-27-303). It is an NIH cooperative agreement (U24; clinical trial not allowed) to support the core coordinating and leadership center for the KPMP consortium.
2) What is the main purpose of the KPMP Central Hub award?
The purpose is to provide the strategic and operational backbone for KPMP and drive a unified, project-wide effort to discover and define new biological pathways and clinically meaningful subgroups across acute kidney disease (AKD) and chronic kidney disease (CKD). The long-term intent is to enable true precision medicine by producing mechanistic and subgroup insights that can inform more targeted precision clinical trials in the future (even though this award itself does not support running clinical trials).
3) What does "Central Hub" mean in this context?
The Central Hub is the core coordinating and leadership center for the KPMP consortium. It is expected to lead and coordinate scientific direction and day-to-day operations across participating sites and teams, keep the consortium aligned on shared goals and standards, and ensure the overall program moves efficiently from data generation to interpretable discoveries.
4) Is NIH funding more than one Central Hub under this announcement?
No. Only one award is expected under this announcement, meaning the selected awardee will serve as the single, primary coordinating entity for KPMP at the national program level.
5) What type of NIH award mechanism is this?
This is an NIH cooperative agreement using the U24 activity code, and clinical trials are not allowed under this award.
6) What does it mean that this is a "cooperative agreement"?
A cooperative agreement typically involves substantial NIH programmatic involvement compared with a standard grant. Under this structure, the awardee is expected to collaborate closely with NIH program staff on governance, milestones, and implementation decisions.
7) Are clinical trials allowed under this funding opportunity?
No. The funding opportunity is explicitly described as "clinical trial not allowed."
8) If clinical trials are not allowed, why does the NOFO mention future precision clinical trials?
The program goal is to generate mechanistic and subgroup insights that make precision medicine possible, including informing better-designed and more targeted clinical trials in the future. However, this particular award does not support running those trials.
9) What diseases and patient populations are the focus of KPMP in this announcement?
The focus is on acute kidney disease (AKD) and chronic kidney disease (CKD), with an emphasis on identifying new biological pathways and clinically meaningful subgroups.
10) What are the Central Hub's scientific responsibilities?
Based on the description provided, the Central Hub is expected to provide high-level scientific leadership across the consortium, actively participate in scientific discovery, help set standards and priorities, and guide analytic approaches that support project-wide discovery and interpretability.
11) What are the Central Hub's computational and data-related responsibilities?
A major emphasis is stewardship of advanced computational analyses and the end-to-end data ecosystem. The Hub is expected to support collecting, organizing, integrating, analyzing, and sharing complex KPMP datasets in ways that enable broad discovery, reproducibility, and downstream use by the research community.
12) What does "end-to-end data ecosystem" imply for the Central Hub?
It implies responsibility across the full data lifecycle described in the opportunity: data collection support, organization, integration across sources, advanced analysis, and data sharing so that outputs are usable, reproducible, and broadly valuable beyond the immediate consortium.
13) What is the open science expectation for this award?
The opportunity emphasizes data management and data sharing practices consistent with open science expectations. The project is designed to promote transparency and community benefit rather than keeping data siloed.
14) Does the Central Hub function as only an administrative coordinating center?
No. The description underscores that KPMP personnel are expected to actively participate in scientific discovery and promote open science, indicating that the Central Hub is intended to be a scientific driver as well as an operational and administrative backbone.
15) What operational and administrative functions are included in the Central Hub scope?
The scope extends into communication, outreach, and business operations. Practically, that includes supporting consortium communications (internal coordination and external engagement), maintaining outreach to disseminate KPMP progress and resources, and handling the operational and administrative functions required to run a complex multi-site program.
16) What is the role of communications and outreach for the Central Hub?
The Central Hub is expected to support internal consortium coordination and external engagement, and to maintain outreach that helps disseminate KPMP progress and resources.
17) What is the overarching outcome KPMP is trying to achieve through this Central Hub?
The overarching outcome is to accelerate discovery of kidney disease mechanisms and patient subgroups in AKD and CKD, laying a foundation for future precision approaches and better-targeted clinical research across kidney diseases.
18) What is the Assistance Listing (CFDA) number for this opportunity?
The Assistance Listing (CFDA) number is 93.847, and it is categorized under the health funding activity area.
19) Who is eligible to apply?
Eligibility is broad across many domestic U.S. organization types, including: state governments; county governments; city or township governments; special district governments; public and state-controlled institutions of higher education; private institutions of higher education; independent school districts; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits (501(c)(3) and non-501(c)(3), excluding higher education in those nonprofit categories as specified); for-profit organizations other than small businesses; small businesses; and other eligible entities as permitted by NIH.
20) Are non-U.S. (foreign) organizations eligible to apply?
No. Non-U.S. entities are not eligible to apply.
21) Can a U.S. organization include a non-U.S. component?
No. The opportunity states that non-U.S. components of U.S. organizations are not eligible.
22) Are foreign components allowed in any form?
No. Foreign components (as defined by the NIH Grants Policy Statement) are not allowed. The supported work and components must be fully domestic under NIH policy for this award.
23) What is the application closing date listed for this opportunity?
The original application closing date listed is July 10, 2026.
24) When was this opportunity created?
The opportunity was created on June 3, 2026.
25) What does it mean that the Central Hub supports "project-wide" coordination?
It means the Central Hub is responsible for coordinating across participating sites and teams within KPMP, aligning shared goals, standards, and deliverables, and helping ensure the entire consortium progresses efficiently and consistently.
26) What kinds of outputs is the Central Hub expected to enable?
Based on the description, the Central Hub is expected to enable outputs such as integrated datasets, advanced computational analyses, reproducible results, and broadly usable shared data resources that support interpretable discoveries and downstream use by the wider research community.
27) Why is reproducibility highlighted in the scope?
The opportunity emphasizes organizing, integrating, analyzing, and sharing complex datasets in ways that enable reproducibility, indicating that results should be verifiable and reusable by others rather than dependent on isolated, non-transparent workflows.
28) How does this award support precision medicine if it is not running clinical trials?
It supports precision medicine by building the mechanistic understanding and clinically meaningful subgroup definitions across AKD and CKD that are needed to design more targeted interventions and future precision clinical trials.
29) What is the expected relationship between the awardee and NIH program staff?
Because this is a cooperative agreement, the awardee is expected to collaborate closely with NIH program staff on governance, milestones, and implementation decisions.
30) What makes this Central Hub role "high complexity"?
It is described as supporting a multi-site, high-complexity program, combining consortium-wide scientific leadership, advanced computational and data-sharing infrastructure stewardship, and substantial communications, outreach, operational, and administrative coordination.
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